Fab’ Fragment‐Immobilized Gold Surface for Capturing EpCAM‐Positive Breast Cancer Cells

<i>Practical application:</i> This study presents a preliminary design of a Fab' fragment-immobilized surface for the selective capture of EpCAM-positive breast cancer cells. The surface modification relies on spontaneous Au-S bonding, offering a simple and effective chemical method. The modified surface demonstrates strong potential for integration into future biosensor platforms for detecting circulating tumor cells. Such a system is promising for advanced diagnostics, monitoring, disease progression, and personalized treatment uses.