Traumatic brain injury, changes in plasma amyloid, tau, and neurodegenerative biomarkers, and dementia risk
Our findings provide evidence that TBI fundamentally alters trajectories of plasma biomarkers of AD-related pathology, neuronal degeneration, and astrogliosis for approximately a decade after the injury. Further, our findings also suggest that an incident TBI event adds to and interacts with ongoing neurodegenerative processes to increase the risk of later life dementia. These results suggest that the pathologic processes underlying post-TBI dementia are heterogeneous, that individuals with preclinical changes in neurodegenerative biomarkers may be more susceptible to TBI (i.e., that associations are bidirectional), or a combination thereof.
Authors
- James Russell Pike (ORCID: https://orcid.org/0000-0002-6858-620X)
- Ramon Diaz‐Arrastia (ORCID: https://orcid.org/0000-0001-6051-3594)
- Andrea L.C. Schneider (ORCID: https://orcid.org/0000-0003-0026-5052)
- Rebecca F. Gottesman (ORCID: https://orcid.org/0000-0002-9504-1256)
- David Krishna Menon (ORCID: https://orcid.org/0000-0002-3228-9692)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Alexa E. Walter (ORCID: https://orcid.org/0000-0002-1056-1966)
- Priya Palta
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Cambridge (GB)
- Bridge University (SS)
- National Institute of Neurological Disorders and Stroke (US)
- New York University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70611
- Citations
- 3
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- U.S. Department of Defense
- National Institute for Health and Care Research
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute on Deafness and Other Communication Disorders
- National Institute of Neurological Disorders and Stroke