Randomized phase III trial of adjuvant radiation versus chemoradiation in intermediate-risk, early-stage cervical cancer following radical hysterectomy and lymphadenectomy: results from NRG Oncology/GOG-263/KGOG 1008
Although RFS and OS favored CRT, the addition of cisplatin during RT did not statistically improve RFS or OS in cervical cancer patients with intermediate pathological risk factors following radical hysterectomy and lymphadenectomy. CRT increased grade 3 and 4 AEs with a transient decline in QoL.
Authors
- Charles A. Leath (ORCID: https://orcid.org/0000-0002-4034-6845)
- Bradley J. Monk (ORCID: https://orcid.org/0000-0001-6985-0159)
- Kevin Albuquerque (ORCID: https://orcid.org/0000-0003-4067-6518)
- C-H Cho
- Dana M. Chase (ORCID: https://orcid.org/0000-0002-1073-8688)
- Jae Hong No (ORCID: https://orcid.org/0000-0002-2389-6757)
- A. Heugel
- William H. Rodgers (ORCID: https://orcid.org/0000-0003-3946-3136)
- Kathryn Miller (ORCID: https://orcid.org/0000-0002-7464-1981)
- Jyoti Mayadev (ORCID: https://orcid.org/0000-0003-4786-8192)
- Dorottya Fabian (ORCID: https://orcid.org/0000-0002-3249-0812)
- Robert S. Mannel
- Wei Deng (ORCID: https://orcid.org/0000-0002-3671-5951)
- Do Young Kim (ORCID: https://orcid.org/0000-0002-0194-9854)
- Sang Young Ryu
- W-J Koh
- BJ Kim
- JW Kim (ORCID: https://orcid.org/0000-0002-0498-5762)
- Karen M. Gil (ORCID: https://orcid.org/0000-0002-0135-6311)
- William Small
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- University of California, Los Angeles (US)
- Loyola University Chicago (US)
- Cornell University (US)
- Oklahoma City University (US)
- University Hospitals of Cleveland (US)
- Asan Medical Center (KR)
- Markey Cancer Center (US)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Korea Institute of Radiological and Medical Sciences (KR)
- Florida Cancer Specialists & Research Institute (US)
- Keimyung University Dongsan Medical Center (KR)
- Women & Infants Hospital of Rhode Island (US)
- National Comprehensive Cancer Network
- Keimyung University (KR)
- The University of Texas Southwestern Medical Center (US)
- University of Oklahoma (US)
- Northeast Ohio Medical University (US)
Publication Details
- Journal
- Annals of Oncology
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1016/j.annonc.2025.09.003
- Citations
- 8
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 16.46