Investigating the oxidative stress–vascular brain injury axis in mild cognitive impairment of the Alzheimer's type
Neuronal, vascular, and oxidative injuries occur in the Alzheimer's disease (AD) spectrum. Glutathione (GSH) is the main endogenous antioxidant in the brain. Brain GSH can be measured with magnetic resonance spectroscopy (MRS). We measured brain GSH level in people with mild cognitive impairment (MCI). Low GSH level was associated with vascular brain injury, neuroaxonal damage, and atrophy.
Authors
- Samson Antel
- Jamie Near (ORCID: https://orcid.org/0000-0003-3516-936X)
- Hyman M. Schipper (ORCID: https://orcid.org/0000-0001-7319-1985)
- Sneha Senthil (ORCID: https://orcid.org/0000-0002-3601-9497)
- Dumitru Fetco (ORCID: https://orcid.org/0000-0003-1335-8274)
- Rozie Arnaoutelis
- David Araújo (ORCID: https://orcid.org/0000-0002-1600-6138)
- Sridar Narayanan (ORCID: https://orcid.org/0000-0002-6283-150X)
- Haz‐Edine Assemlal
- Douglas Lorne Arnold (ORCID: https://orcid.org/0000-0003-4266-0106)
- Chris Hosein
- AmanPreet Badhwar (ORCID: https://orcid.org/0000-0003-3414-3395)
- Flavie E. Detcheverry (ORCID: https://orcid.org/0000-0002-9909-9754)
- Winnie L. K. Motue
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Montreal Heart Institute (CA)
- McGill University Health Centre (CA)
- Jewish General Hospital (CA)
- Institute for Neurodegenerative Disorders (US)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Sunnybrook Research Institute
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70456
- Citations
- 2
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- Courtois Foundation
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé