Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome
White matter hyperintensity (WMH) volume increased and decreased over time in adults with Down syndrome. WMH decreased over time in the cognitively stable group. WMH increased over time in advanced Alzheimer's disease diagnostic groups. Change in posterior WMH accelerated across progressive Alzheimer's disease groups.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Natalie Edwards (ORCID: https://orcid.org/0000-0002-0800-5274)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Donna M. Wilcock (ORCID: https://orcid.org/0000-0003-3388-1564)
- Batool M. Rizvi (ORCID: https://orcid.org/0000-0001-9120-3943)
- Juyoung Hahm
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Roberta Lemay
- José Gutierrez (ORCID: https://orcid.org/0000-0002-2175-8078)
- Mohamad J. Alshikho
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Mark E. Mapstone (ORCID: https://orcid.org/0000-0003-0280-8057)
- Michael A. Yassa (ORCID: https://orcid.org/0000-0002-8635-1498)
- Anna Smith (ORCID: https://orcid.org/0000-0002-1365-0809)
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
- Lisi Flores Aguilar (ORCID: https://orcid.org/0000-0002-7962-7433)
- H. Diana Rosas
Institutions
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70679
- Citations
- 2
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Alzheimer's Association
- National Institutes of Health
- National Institute on Aging
- National Center for Advancing Translational Sciences