Troxerutin improves diabetic cognitive dysfunction by inhibiting mitochondrial fission mediated by transient receptor potential melastatin 7/calcineurin/dynamin-related protein 1 <sup>ser637</sup>
TRPM7 promotes mitochondrial fission <i>via</i> the CaN/Drp1<sup>ser637</sup> pathway. Troxerutin improves mitochondrial function and reduces neuronal damage by inhibiting this pathway, suggesting TRPM7 as a potential therapeutic target for DCD.
Authors
- Ming Gao (ORCID: https://orcid.org/0000-0002-2743-2247)
- Jie Li (ORCID: https://orcid.org/0000-0002-1059-280X)
- Ai-Jing Liu
- Hongyan Li (ORCID: https://orcid.org/0000-0001-7260-2957)
- Pin Wang (ORCID: https://orcid.org/0000-0001-8939-5413)
- Fang Yuan (ORCID: https://orcid.org/0000-0002-2590-1572)
- Songyun Zhang
- Jiaxin Wang (ORCID: https://orcid.org/0009-0003-1445-2358)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-08-14
- DOI
- https://doi.org/10.4239/wjd.v16.i8.106833
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.00