Higher glycated hemoglobin amplifies the effect of apolipoprotein E epsilon 4-related cognition and olfaction impairments in type 2 diabetes
Elevated HbA1c levels are associated with increased risks of cognitive and olfactory impairments in patients with T2DM and may exacerbate the detrimental effects of APOE4. These findings underscore the need for early preventive strategies targeting individuals with both poor glycemic control and APOE4 carriage to mitigate neurodegenerative risk.
Authors
- Yang Gao (ORCID: https://orcid.org/0000-0001-9533-7121)
- Haibo Xu (ORCID: https://orcid.org/0000-0002-8451-8979)
- Yuying Wang (ORCID: https://orcid.org/0009-0000-3482-4110)
- Yao Zhang (ORCID: https://orcid.org/0000-0001-9314-5820)
- Zhipeng Xu (ORCID: https://orcid.org/0000-0001-7957-547X)
- Jian‐Zhi Wang (ORCID: https://orcid.org/0009-0000-2068-6749)
- Yarong Wang (ORCID: https://orcid.org/0000-0002-0551-5412)
- Yanchao Liu (ORCID: https://orcid.org/0000-0003-2053-7289)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Huazhong University of Science and Technology Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-08-14
- DOI
- https://doi.org/10.4239/wjd.v16.i8.106664
- Citations
- 1
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 1.32