Infusion of blood from young and old mice modulates amyloid pathology
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of misfolded proteins in the brain. Recently, the impact of blood components in the progression of this disease has come to attention. This study investigates the effects of infusing blood from young and old wild-type mice into transgenic mice that model AD brain amyloidosis. Impaired memory and Aβ accumulation were observed in mice infused with blood from old donors. A proteomic analysis in the brain of these mice identified alterations in components related to synaptogenesis and the endocannabinoid system. The α2δ2 protein, associated with neuronal calcium regulation, was validated as a possible mediator of the observed effects. This study highlights the influence of blood in AD pathology and the identification of potential therapeutic targets.
Authors
- Matías Pizarro (ORCID: https://orcid.org/0009-0005-7397-1515)
- Cristian A. Vargas (ORCID: https://orcid.org/0000-0002-1486-3611)
- Claudia A. Duran-Aniotz (ORCID: https://orcid.org/0000-0003-2503-8366)
- Carmen Ayuso Valdés (ORCID: https://orcid.org/0009-0008-7317-6564)
- Rodrigo Morales (ORCID: https://orcid.org/0000-0001-7766-5770)
- Ariel Caviedes (ORCID: https://orcid.org/0000-0003-4373-5587)
- Ruben Gomez‐Gutierrez (ORCID: https://orcid.org/0000-0001-9134-4375)
- Ute Woehlbier (ORCID: https://orcid.org/0000-0003-3114-9708)
- Mauricio Hernández (ORCID: https://orcid.org/0000-0002-2277-0132)
Institutions
- Universidad Mayor (CL)
- Adolfo Ibáñez University (CL)
- Universidad Bernardo O'Higgins (CL)
- Saint John's School (CL)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Aging
- Published
- 2025-09-12
- DOI
- https://doi.org/10.18632/aging.206319
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Agencia Nacional de Investigación y Desarrollo
- National Institutes of Health
- National Institute on Aging
- Fogarty International Center