Authors' reply to letter regarding “Inflammaging links life's essential 8 to white matter brain aging”
We want to thank Dr. Grimolizzi's letter following up our study on Life's Essential 8 (LE8) and white matter brain aging.1 It is indeed of clinical interest to learn the underlying biological mechanism on how higher LE8 score helps maintain the integrity of white matter. We have previously found allostatic load (AL), a multi-system measure of the cumulative “wear and tear” on the body which includes inflammation,2 accelerated white matter brain aging.3
Authors
- Tianzhou Ma (ORCID: https://orcid.org/0000-0003-3605-0811)
- Zhenyao Ye
- Feng Li (ORCID: https://orcid.org/0000-0001-7423-8730)
- Shuo Chen (ORCID: https://orcid.org/0000-0002-0678-7380)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105909
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00