Extracellular Vesicles as a Platform for Predicting Cancer Risk in Patients with Adenomas and Polyps of the Colon with Obesity
The advantages of the calculated mathematical model are as follows: 1) the parameters included in the model are estimated in the blood plasma EVs, thereby not requiring invasive procedures (colonoscopy, biopsy sampling); 2) the model takes into account the presence of metabolic disorders, since the model includes subpopulations of CD9-positive vesicles and FABP4-positive (adipocyte-derived) EVs as predictors of cancer risk; 3) the calculation of cancer risk using this model can be repeated. This version of the application of the model can consider changes in cancer risk and allows optimization of management tactics for CA patients.
Authors
- Е. С. Колегова (ORCID: https://orcid.org/0000-0001-9122-3274)
- А. Л. Чернышова (ORCID: https://orcid.org/0000-0002-8194-2811)
- S. G. Afanasyev (ORCID: https://orcid.org/0000-0002-4701-0375)
- Dmitry A. Svarovsky (ORCID: https://orcid.org/0000-0002-8985-009X)
- D. N. Kostromitsky (ORCID: https://orcid.org/0000-0001-5691-2349)
- N. V. Yunusova (ORCID: https://orcid.org/0000-0003-4595-4177)
- Л. В. Спирина (ORCID: https://orcid.org/0000-0002-5269-736X)
- E. E. Sereda (ORCID: https://orcid.org/0000-0002-7752-9346)
- Г. В. Какурина (ORCID: https://orcid.org/0000-0002-4506-9429)
- О. В. Черемисина (ORCID: https://orcid.org/0000-0001-7234-4708)
Institutions
- Siberian State Medical University (RU)
- Tomsk National Research Medical Center (RU)
- Meshalkin National Medical Research Center (RU)
Publication Details
- Journal
- Asian Pacific Journal of Cancer Prevention
- Published
- 2025-09-01
- DOI
- https://doi.org/10.31557/apjcp.2025.26.9.3431
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research Institute