Genome‐wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures
Genome-wide significant pleiotropy in blood pressure (BP) and cognitive performance measures were identified with 11 novel loci: JPH2, GATA3, PAX2, LOC105371656, SUFU in the total sample; RTN4, ULK2, SORBS2, LOC100128993 in prospective cohorts; and ADAMTS3, LINC02946 in clinic-based cohorts. SUFU, RTN4, SORBS2, ADAMTS3, and GATA3 affected cognition directly rather than through BP. ACTR1A, HIF1AN, ADAMTS3, RTN4, SORBS2, and SUFU at pleiotropic loci were differentially expressed among controls and pathologically confirmed AD cases with and without clinical symptoms.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Moon-Il Kang (ORCID: https://orcid.org/0000-0001-5932-6804)
- Rhoda Au (ORCID: https://orcid.org/0000-0001-7742-4491)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Michael K. Lee (ORCID: https://orcid.org/0000-0001-5865-9682)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Ting Fang Alvin Ang (ORCID: https://orcid.org/0000-0003-4687-2552)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Sherral Devine (ORCID: https://orcid.org/0000-0002-5063-6651)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Connie Nakano
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Phoebe Scollard
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Richard Sherva (ORCID: https://orcid.org/0000-0003-2133-1493)
- Kathryn L. Lunetta (ORCID: https://orcid.org/0000-0002-9268-810X)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- David A. Bennett
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Margaret A. Pericak‐Vance
- Li-San Wang
- Gerard D. Schellenberg
Institutions
- Boston University (US)
- Rush University Medical Center (US)
- University of Puget Sound (US)
- University of Washington (US)
- VA Puget Sound Health Care System (US)
- Geriatric Research Education and Clinical Center (US)
- Framingham Heart Study (US)
- Dr. John T. Macdonald Foundation (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70681
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- University of Pennsylvania
- National Institutes of Health
- National Institute on Aging