Targeting WWPI HECT Domain by Small Inhibitors for Restoring PTEN Tumor Suppressive Role in Glioblastoma Therapy
This study has discovered novel inhibitors against the WWPI HECT domain, and a treatment option for glioblastoma.
Authors
- Sobia Ahsan Halim (ORCID: https://orcid.org/0000-0001-8526-7799)
- Najeeb Ur Rehman (ORCID: https://orcid.org/0000-0002-1563-225X)
- Sadeeq ur Rahman (ORCID: https://orcid.org/0000-0002-9314-6257)
- Ajmal Khan (ORCID: https://orcid.org/0000-0002-6124-7459)
- Magda H. Abdellattif (ORCID: https://orcid.org/0000-0002-8562-4749)
- Ahmed Al‐Harrasi (ORCID: https://orcid.org/0000-0002-0815-5942)
- Atta Ullah (ORCID: https://orcid.org/0009-0003-1582-9460)
- Majid Khan
- Alaa Abu Alnjaa
- Usama Qayum
- Magdy Mohamed Ahmed Elshamy
Institutions
- Taif University (SA)
- Abdul Wali Khan University Mardan (PK)
- Korea University (KR)
- Umm al-Qura University (SA)
- University of Nizwa (OM)
- University of Tabuk (SA)
- Fuzhou University (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-09-09
- DOI
- https://doi.org/10.2174/0118715206387854250811103423
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00