Low-dose valproic acid ameliorates osteoporosis by restoring redox homeostasis and suppressing ferritinophagy-dependent ferroptosis via EZH2/H3K27me3 signaling
Low-dose VPA ameliorates osteoporosis by restoring redox homeostasis, epigenetically inhibiting NCOA4-mediated ferritinophagy via EZH2/H3K27me3 activation, and suppressing osteoclastogenesis. These findings identify low-dose VPA as a multifaceted anti-osteoporotic agent and highlight the EZH2/H3K27me3/NCOA4 axis as a pivotal regulatory pathway in bone redox biology.
Authors
- Yifan Gu (ORCID: https://orcid.org/0000-0001-7669-5046)
- Run Feng
- Y. Wang (ORCID: https://orcid.org/0000-0002-0271-626X)
- Min Yang (ORCID: https://orcid.org/0000-0003-1231-3269)
- Kun Wang (ORCID: https://orcid.org/0000-0001-5342-5967)
- Ziru Wang (ORCID: https://orcid.org/0000-0003-4633-3161)
- Shuai Jiang (ORCID: https://orcid.org/0000-0003-0239-1597)
- Yu Zheng (ORCID: https://orcid.org/0009-0002-9169-6105)
- Yi‐Heng Li
Institutions
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.09.023
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81