A fluorogenic probe for screening aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors
We report the first competitive aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor featuring a fluorogenic binding response and nanomolar affinity (<i>K</i><sub>D</sub>), enabling real-time screening of non-fluorescent inhibitors with high cellular compatibility and no observed toxicity.
Authors
- Shilpendu Ghosh (ORCID: https://orcid.org/0000-0003-0487-6598)
- Rahul Das (ORCID: https://orcid.org/0000-0001-7841-8229)
- Arindam Mukherjee (ORCID: https://orcid.org/0000-0001-9545-8628)
- Soumee SenGupta
- S Mukherjee (ORCID: https://orcid.org/0009-0003-1700-0293)
- S. Ghosh (ORCID: https://orcid.org/0009-0006-7512-1503)
- Bidhan Chandra Roy (ORCID: https://orcid.org/0000-0003-1941-6682)
- Aniket Majee
Institutions
- Indian Institute of Science Education and Research Kolkata (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03947a
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94