Nanopore sequencing-derived methylation biomarker prediction for methylation-specific PCR in patients with head and neck squamous cell carcinoma
Our resulting DNA methylation-based workflow demonstrates how long-read methylation data enable the design of adaptable, clinically relevant epigenetic assays, even with low coverage and small initial sample numbers.
Authors
- Anna-Bawany Hums
- Daria Meyer (ORCID: https://orcid.org/0000-0003-2006-4610)
- Orlando Guntinas‐Lichius (ORCID: https://orcid.org/0000-0001-9671-0784)
- Martina Schmitz (ORCID: https://orcid.org/0000-0003-2430-3500)
- Manja Marz
- Anne K. Hennig
Institutions
- German Centre for Integrative Biodiversity Research (DE)
- Max Planck Institute for Evolutionary Anthropology (DE)
- Jena University Hospital (DE)
- oncgnostics (Germany) (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1186/s13148-025-01960-7
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61