Impact of different preferred functional outcomes on the results of the pre-hospital antifibrinolytics for traumatic coagulopathy and hemorrhage (PATCH-trauma) trial
The assessment of TXA therapy's efficacy and safety may vary depending on scenarios where certain functional outcomes are considered worse than death. This analytical approach could inform functional outcome assessment in future acute care trials.
Authors
- Marc Maegele (ORCID: https://orcid.org/0000-0002-0634-4723)
- Russell L. Gruen (ORCID: https://orcid.org/0000-0001-8023-1957)
- Andrew Forbes (ORCID: https://orcid.org/0000-0003-4269-914X)
- Paul Jeffrey Young (ORCID: https://orcid.org/0000-0002-3428-3083)
- Biswadev Mitra (ORCID: https://orcid.org/0000-0002-0508-2450)
- Colin J. McArthur (ORCID: https://orcid.org/0000-0003-0370-0080)
- Daniel Gärtner (ORCID: https://orcid.org/0000-0003-4361-8559)
- Fernando Godinho Zampieri (ORCID: https://orcid.org/0000-0001-9315-6386)
- Brian Burns (ORCID: https://orcid.org/0000-0002-8794-0710)
- Stephen Bernard
Institutions
- Australian National University (AU)
- University of Alberta (CA)
- Witten/Herdecke University (DE)
- Royal North Shore Hospital (AU)
- Auckland City Hospital (NZ)
- The Alfred Hospital (AU)
- Ambulance Victoria (AU)
- Victoria University of Wellington (NZ)
- Australian and New Zealand Intensive Care Society (AU)
- Monash Alfred Psychiatry Research centre (AU)
- Medical Research Institute of New Zealand (NZ)
- National Trauma Research Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- Journal of Critical Care
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1016/j.jcrc.2025.155255
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00