Hydroxyethyl methacrylate is genotoxic but not mutagenic in human gingival fibroblasts as assessed by Duplex Sequencing

Although HEMA has potentially mutagenic properties such as the formation of ROS and genotoxicity, no HEMA-induced mutations could be detected in HGF using DS under the specific experimental conditions and concentrations investigated. We posit that, during the recovery phase, either damaged DNA is repaired or apoptosis is initiated.