Single-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure
Our findings provide a comprehensive atlas of BAT cellular heterogeneity and reveal a critical role for ChREBP in lipogenic adipocyte identity, with implications for BAT plasticity and metabolic function.
Authors
- Jöerg Heeren (ORCID: https://orcid.org/0000-0002-5647-1034)
- Lorenz Adlung (ORCID: https://orcid.org/0000-0002-0971-2309)
- Mark A. Herman (ORCID: https://orcid.org/0000-0001-6979-103X)
- Christoph Kilian (ORCID: https://orcid.org/0000-0003-0933-6152)
- Janina Behrens (ORCID: https://orcid.org/0000-0002-9723-8087)
- Anna Worthmann (ORCID: https://orcid.org/0000-0002-4731-3974)
- Ludger Scheja (ORCID: https://orcid.org/0000-0001-5315-7325)
- Tongtong Wang (ORCID: https://orcid.org/0009-0002-0408-7556)
Institutions
- Universität Hamburg (DE)
- Baylor College of Medicine (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Nutrition Sciences (Belgium) (BE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1016/j.molmet.2025.102252
- Citations
- 5
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 8.15