Characterization of genes involved in hemoglobin degradation in Plasmodium vivax isolates from Chennai, India, and species of non-human primate malaria
The genes were highly conserved across isolates, underscoring their important (essential) roles in parasite survival and their potential as drug targets. These are the first findings from the Indian subcontinent that provide critical insights into the mechanisms of chloroquine (CQ) action and resistance, paving the way for novel therapeutic strategies against Plasmodium vivax malaria.
Authors
- Surendra K. Prajapati (ORCID: https://orcid.org/0000-0003-1188-668X)
- Hema Joshi
- Sneh Shalini (ORCID: https://orcid.org/0009-0000-0121-6733)
- Sonia Verma (ORCID: https://orcid.org/0000-0001-8828-9096)
- Neelima Mishra (ORCID: https://orcid.org/0000-0003-1361-6077)
- Sonal Kale (ORCID: https://orcid.org/0000-0002-0085-7202)
- O. P. Singh (ORCID: https://orcid.org/0000-0001-5135-6654)
- Prashant K. Mallick (ORCID: https://orcid.org/0000-0002-5866-717X)
- Anil Kumar (ORCID: https://orcid.org/0000-0002-1542-977X)
- Nalini Srivastava
- Alex Eapen (ORCID: https://orcid.org/0000-0002-2511-2557)
Institutions
- Jiwaji University (IN)
- GD Goenka University (IN)
- National Institute of Epidemiology (IN)
- National Institute of Malaria Research (IN)
Publication Details
- Journal
- Infection Genetics and Evolution
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1016/j.meegid.2025.105823
- Primary Topic
- Digital Imaging for Blood Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00