Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial
FA improved cognitive outcomes in CSVD-CI, accompanied by a reduction in serum Hcy levels and MMP-9 expression. Early FA supplementation could help prevent vascular-related cognitive decline in CSVD-CI patients.
Authors
- Yinyue Liu
- Zi‐Li Yu (ORCID: https://orcid.org/0000-0003-0728-8564)
- Yajie Guo (ORCID: https://orcid.org/0000-0001-5473-207X)
- Bin Yi (ORCID: https://orcid.org/0000-0001-5840-2086)
- Yu Wang (ORCID: https://orcid.org/0000-0003-1253-7465)
- Xumei Zhang (ORCID: https://orcid.org/0000-0002-0944-6397)
- Li Zhao
- Zhijun Cai
- Xiaonan Su
- Yu Miao
Institutions
- Changzhi Medical College (CN)
- National Institutes of Pharmaceutical Research and Development (China) (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100369
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00