Thyroid hormone receptor blockade by amiodarone disrupts angiogenesis via <scp>VEGFα</scp>, <scp>WNT7A</scp>, <scp>BMP</scp>, and <scp>PI3K</scp>/<scp>AKT</scp> pathways in chick embryo vascular development
Our findings underscore the essential role of thyroid hormone signaling in embryonic angiogenesis. Disruption of TR activation by amiodarone significantly impairs vascular formation through coordinated suppression of Vascular endothelial growth factor alpha (VEGFα), WNT7A, bone morphogenetic proteins, and PI3K/AKT pathways. These insights enhance our understanding of TH-related developmental disorders and may guide therapeutic strategies for managing vascular dysfunctions associated with impaired thyroid signaling.
Authors
- Juhi Vaishnav (ORCID: https://orcid.org/0000-0002-7209-5374)
- Suresh Balakrishnan (ORCID: https://orcid.org/0000-0002-6559-022X)
Institutions
- Maharaja Sayajirao University of Baroda (IN)
Publication Details
- Journal
- Developmental Dynamics
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1002/dvdy.70076
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81