Eculizumab and ravulizumab clinical trial and real-world pharmacovigilance of meningococcal infections across indications

Meningococcal infection and mortality reporting rates have remained stable despite increasing cumulative eculizumab and ravulizumab exposure over time across indications, including rare neurological indications. Infection awareness, existing risk mitigation strategies, and availability of vaccines have effectively reduced the risk of meningococcal infections in C5IT-treated patients, underlining the importance of adhering to those measures.