Impact of Genotype–Phenotype Associations on Prognosis in Dilated Cardiomyopathy
Patients with a genetic form of DCM exhibit clinical and genetic heterogeneity. Genotype-based risk stratification is more accurate compared to a phenotype-first approach, highlighting the importance of broad genetic screening among patients with DCM. Additionally, gene-specific risk prediction should become more prominent in current guidelines on management of genetic DCM patients.
Authors
- Sharon Graw (ORCID: https://orcid.org/0000-0003-4577-1493)
- Job A.J. Verdonschot (ORCID: https://orcid.org/0000-0001-5549-1298)
- Nerea Mora Ayestarán (ORCID: https://orcid.org/0000-0002-2127-5287)
- Kristen Medo (ORCID: https://orcid.org/0009-0007-9785-4668)
- Sophie L.V.M. Stroeks (ORCID: https://orcid.org/0000-0003-0965-6359)
- Gianfranco Sinagra (ORCID: https://orcid.org/0000-0003-2700-8478)
- Fernándo Domínguez (ORCID: https://orcid.org/0000-0001-8408-363X)
- Max F.G.H.M. Venner (ORCID: https://orcid.org/0009-0001-2574-6672)
- Steven A. Muller (ORCID: https://orcid.org/0000-0002-2674-8709)
- Marco Merlo (ORCID: https://orcid.org/0000-0002-1022-3131)
- Matteo Dal Ferro (ORCID: https://orcid.org/0000-0002-2310-0448)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- Stéphane Heymans (ORCID: https://orcid.org/0000-0001-9477-7803)
- Matthew R.G. Taylor (ORCID: https://orcid.org/0000-0001-9043-0810)
- Maurits A. Sikking (ORCID: https://orcid.org/0000-0001-8165-6631)
- Luisa Mestroni (ORCID: https://orcid.org/0000-0003-1116-2286)
- Bart de Koning (ORCID: https://orcid.org/0000-0002-6979-1731)
- Alessia Paldino (ORCID: https://orcid.org/0000-0002-5823-3777)
- J. Peter van Tintelen (ORCID: https://orcid.org/0000-0003-3854-6749)
- Anneline S.J.M. te Riele (ORCID: https://orcid.org/0000-0002-4694-4790)
- Michiel Minten
- Ping Wang (ORCID: https://orcid.org/0000-0002-8876-4210)
- Esther Gonzalez-Lopez
- Max Jason (ORCID: https://orcid.org/0009-0003-1492-2276)
- Arthur van den Wijngaard
- Bastien Nihant
- Nina J Beelen (ORCID: https://orcid.org/0009-0008-0605-4604)
- Carola Pio Loca
Institutions
- Utrecht University (NL)
- University Medical Center (US)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Centro Nacional de Epidemiología (ES)
- Centro Nacional de Biotecnología (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Netherlands Heart Institute (NL)
- Spanish National Centre for Cardiovascular Research (ES)
- ERN GUARD-Heart (NL)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- University of Colorado Anschutz Medical Campus (US)
- KU Leuven (BE)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1002/ejhf.70040
- Citations
- 4
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- HORIZON EUROPE European Innovation Council