Iron-Catalyzed Carboxylation of Pyridylphosphonium Salts with CO<sub>2</sub>
Iron is the most abundant transition metal on earth and exhibits the lowest toxicity. However, the iron-catalyzed carboxylation reaction utilizing CO<sub>2</sub> remains significantly underexplored. Here we report an efficient iron-catalyzed carboxylation of pyridylphosphonium salts with CO<sub>2</sub>, which enables the synthesis of a variety of high value-added isoniazid derivatives. This reaction demonstrates excellent tolerance for a wide range of functional groups and possesses high synthetic practicality. The primary catalytic cycle in this reaction may involve an Fe(0)-Fe(I)-Fe(II)-Fe(0) redox sequence.
Authors
- Shibiao Tang
- Baiquan Wang (ORCID: https://orcid.org/0000-0003-4605-1607)
- Bin Li (ORCID: https://orcid.org/0000-0003-3909-3796)
Institutions
- Chinese Academy of Sciences (CN)
- Nankai University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Gannan Medical University (CN)
- State Key Laboratory of Organometallic Chemistry
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1021/acs.joc.5c01797
- Citations
- 1
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.70