ETS2 targets ZMYND11 to inhibit thyroid cancer progression via the mTOR signaling pathway
This study identified the cellular senescence gene ETS2 as a tumor suppressor in THCA, which interacts with ZMYND11 to regulate THCA tumor progression through the mTOR pathway, thereby inhibiting cell senescence. Targeting the ETS2-ZMYND1 axis may provide new therapeutic strategies and prognostic biomarkers for THCA.
Authors
- Jun Jiang (ORCID: https://orcid.org/0009-0000-3404-2071)
- Chenchen Wei (ORCID: https://orcid.org/0000-0002-8181-9696)
- Liming Ma (ORCID: https://orcid.org/0000-0001-9319-5828)
- Chaofeng Chen
- Xiao Xie (ORCID: https://orcid.org/0000-0002-5241-6900)
- Taipengfei Shu
- Wen Shi (ORCID: https://orcid.org/0000-0002-6624-2331)
- Jie Zhou (ORCID: https://orcid.org/0000-0001-5964-1599)
- Lei Jiang (ORCID: https://orcid.org/0000-0002-3841-1169)
- Ping Zhu (ORCID: https://orcid.org/0000-0002-8391-4945)
- Yan Yan (ORCID: https://orcid.org/0000-0002-3968-1320)
- Tao Yu (ORCID: https://orcid.org/0000-0003-4936-8861)
- Yujie Huang (ORCID: https://orcid.org/0000-0003-4152-6896)
- Ning Ji (ORCID: https://orcid.org/0000-0002-2896-5205)
- Chao Shen (ORCID: https://orcid.org/0000-0002-4708-127X)
- Ting Yan
- Xinhua Wu
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Fudan University (CN)
- Minhang District Central Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1371/journal.pone.0328881
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00