Hypoxia Induces Immunosuppression by Silencing STING in Cancer
Hypoxia silences STING expression in a HIF1α-dependent manner that is mediated by KDM1A/KDM5A and oncometabolites, which can be reversed by targeting KDM1A as a potential strategy for enhancing cancer therapy responses.
Authors
- Yuhong Lü (ORCID: https://orcid.org/0009-0006-0744-5338)
- Peter M. Glazer (ORCID: https://orcid.org/0000-0003-4525-5560)
- Yanfeng Liu (ORCID: https://orcid.org/0009-0003-8252-4288)
- Annali M. Yurkevicz (ORCID: https://orcid.org/0000-0003-4740-8639)
Institutions
- Yale University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1158/0008-5472.can-24-2038
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80