Call for timely prevention in thyroid eye disease: lessons from the IrTED registry

Given the potential for targeted interventions such as smoking cessation, identifying high-risk relatives of thyroid dysfunction cases could help minimise disease progression and associated complications (primary prevention). Men and elderly patients are more likely to experience delayed diagnosis, leading to more severe presentations of TED (secondary prevention). Approximately one-fourth of patients had active TED, requiring anti-inflammatory treatment. However, the Clinical Activity Score threshold of 3 did not detect 34.91% of these active cases (tertiary prevention).