High-plex imaging of hepatoblastoma and adjacent liver in pediatric patients reveals a predominant myeloid infiltrate expressing immune-checkpoints
The absence of immune checkpoints and exhaustion markers in CD8<sup>+</sup> T cells prohibits T cell-targeting by immune checkpoint blockade in HB patients. Instead, HB tissue contains a large myeloid compartment expressing myeloid checkpoints VISTA and SIRPα. This could provide opportunities for macrophage targeting and promote the development of improved treatment strategies for HB patients.
Authors
- Lianne J. Kraaier (ORCID: https://orcid.org/0000-0003-2796-3512)
- Marius C. van den Heuvel (ORCID: https://orcid.org/0000-0001-6985-7107)
- Jeanette H.W. Leusen (ORCID: https://orcid.org/0000-0003-4982-6914)
- Kristof Van Avondt
- Vincent Erwin de Meijer (ORCID: https://orcid.org/0000-0002-7900-5917)
- Kathelijne C.J.M. Kraal (ORCID: https://orcid.org/0000-0001-9630-0814)
- Ronald R. de Krijger (ORCID: https://orcid.org/0000-0001-6871-1296)
- Daniëlle Krijgsman (ORCID: https://orcid.org/0000-0001-6101-7146)
- Yvonne Vercoulen (ORCID: https://orcid.org/0000-0002-5060-2603)
- Weng Chuan Peng (ORCID: https://orcid.org/0000-0001-5467-5458)
- József Zsíros
- Ruben H J de Kleine (ORCID: https://orcid.org/0000-0003-3975-3184)
- Meggy E.L. Verdonschot (ORCID: https://orcid.org/0009-0001-5030-856X)
- Yuyan Lu (ORCID: https://orcid.org/0009-0000-6374-1357)
- Stephanie A Schubert (ORCID: https://orcid.org/0000-0002-8655-1350)
Institutions
- University Medical Center Groningen (NL)
- Utrecht University (NL)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- Princess Máxima Center (NL)
- Center for Translational Molecular Medicine (NL)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1007/s00262-025-04164-3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00