Two-Week Course versus Conventionally Fractionated Preoperative Chemoradiotherapy Followed by Total Mesorectal Excision in Locally Advanced Rectal Cancer (Twoarc Trial)
This phase III randomized controlled trial suggests that two-week course of preoperative CRT provides comparable tumor response as standard long-course CRT in rectal cancer, with potential advantages of shorter treatment duration and lower gastrointestinal toxicity.
Authors
- Mina Yu (ORCID: https://orcid.org/0000-0002-4691-4938)
- Kyu Hye Choi (ORCID: https://orcid.org/0000-0001-6446-6377)
- In Kyu Lee (ORCID: https://orcid.org/0000-0001-9074-5214)
- Changhyeok An
- Bae Kwon Jeong (ORCID: https://orcid.org/0000-0001-8015-6061)
- Hyeon‐Min Cho (ORCID: https://orcid.org/0000-0002-7183-2838)
- Bong‐Hyeon Kye (ORCID: https://orcid.org/0000-0002-5251-990X)
- Sung Hwan Kim (ORCID: https://orcid.org/0000-0002-6888-774X)
- Hyung Jin Kim (ORCID: https://orcid.org/0000-0002-6315-714X)
- Yoon Suk Lee (ORCID: https://orcid.org/0000-0002-5835-9417)
- Jong Hoon Lee (ORCID: https://orcid.org/0009-0004-1292-9957)
- Hong Seok Jang
Institutions
- Gyeongsang National University Hospital (KR)
- St. Mary's Hospital (US)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- The Catholic University of Korea Bucheon St. Mary's Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1097/sla.0000000000006942
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00