Lenvatinib Versus Atezolizumab Plus Bevacizumab as First‐Line Treatment for Advanced Hepatocellular Carcinoma With a CRAFITY Score of 2: A Multi‐Center Retrospective Study
Lenvatinib provided a significantly longer PFS than Atezo+Bev in patients with HCC and a baseline CRAFITY score of 2, whereas OS did not significantly differ between the two groups. These findings may serve as a cornerstone for developing biomarker-based strategies in first-line treatment selection for this patient population.
Authors
- Yuji Eso (ORCID: https://orcid.org/0000-0003-4426-1491)
- Shujiro Yazumi (ORCID: https://orcid.org/0000-0002-0683-0000)
- Masako Mishima (ORCID: https://orcid.org/0000-0001-6997-2084)
- Hiroshi Seno (ORCID: https://orcid.org/0000-0002-8509-8128)
- Shigeharu Nakano (ORCID: https://orcid.org/0000-0002-1008-459X)
- Satoru Iwamoto
- Taro Ueo
- Takahisa Kayahara
- Takeshi Seta (ORCID: https://orcid.org/0000-0002-3057-6284)
- Shin’ichi Miyamoto (ORCID: https://orcid.org/0000-0003-2298-0970)
- Atsushi Takai (ORCID: https://orcid.org/0000-0002-5233-4120)
- Yukio Osaki
- Etsuro Hatano (ORCID: https://orcid.org/0000-0003-3407-1918)
- Yoshito Uenoyama (ORCID: https://orcid.org/0000-0003-4967-0059)
- Ken Takahashi (ORCID: https://orcid.org/0000-0002-7310-2257)
- Hiroki Morimura
- Hiroyuki Marusawa (ORCID: https://orcid.org/0000-0002-4286-2712)
- Haruhiko Takeda (ORCID: https://orcid.org/0000-0002-8954-9133)
- Masayuki Ueno (ORCID: https://orcid.org/0000-0002-2497-9327)
- Atsuyuki Ikeda (ORCID: https://orcid.org/0000-0002-0933-3106)
- Tomoyuki Gotō (ORCID: https://orcid.org/0000-0003-0754-4724)
- Shunsuke Okuyama
- Shu Nagatomo
- Makoto Umeda
- Tadashi Inuzuka
- Norihiro Nishijima
- Kazuyoshi Matsumura
Institutions
- Kyoto University (JP)
- Tenri Hospital (JP)
- Kyoto Medical Center (JP)
- Kurashiki Central Hospital (JP)
- Miwa Hospital (JP)
- Kyoto College of Medical Science (JP)
- Parker Institute for Cancer Immunotherapy (US)
- Hyogo Prefectural Amagasaki General Medical Center (JP)
- Kyoto Katsura Hospital (JP)
- Osaka Red Cross Hospital (JP)
- Hyogo Prefectural Nishinomiya Hospital (JP)
- Japanese Red Cross Society Wakayama Medical Center (JP)
- Shiga Medical Center (JP)
- Kitano Hospital (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1111/hepr.70040
- Citations
- 2
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.64