Discovery of a Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening
CHP-9 exhibited significant tyrosinase inhibition (28.57% at 1% concentration) and reduced melanin content in melanocytes, while maintaining over 90% cell viability at effective doses. These findings suggest that CHP-9 is a safe and effective candidate for cosmetic skin-lightening applications. Further research is needed to enhance formulation stability and evaluate long-term efficacy in vivo.
Authors
- Jiahua Cui (ORCID: https://orcid.org/0000-0001-7164-6851)
- Shah Nawaz Khan (ORCID: https://orcid.org/0000-0002-3052-3510)
- Huailong Chang (ORCID: https://orcid.org/0000-0003-3994-6234)
- Kan Tao (ORCID: https://orcid.org/0000-0003-4451-0929)
- Jia Jin-ping
- Hu Huang
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Chengtou (China) (CN)
- University of Malakand (PK)
Publication Details
- Journal
- Skin Research and Technology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/srt.70207
- Citations
- 1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 1.15