A tris(pyrazolyl)-based model for the aminocyclopropane carboxylic acid oxidase and its behavior towards oxidants
A low-molecular-weight analog of the 1-aminocyclopropane carboxylic acid oxidase (ACCO), [Tp<sup>Mes</sup>FeACC], 1, where the (His₂Asp)iron(II) moiety is mimicked by a hydrotris(3-mesitylpyrazol-1-yl)borato iron(II) unit, to which the natural substrate aminocyclopropane carboxylate is coordinated, has been accessed and structurally characterized. It was found to react slowly with O<sub>2</sub> to yield the biological product ethylene. To create models of the intermediates proposed as part of the catalytic cycle of the ACCO 1 was treated with tBuOOH and mCPBA at low temperatures, which generated the respective Fe<sup>III</sup>OOtBu and Fe<sup>IV</sup>=O intermediates as shown by spectroscopic analysis. Studies on their behavior upon annealing reveal a non-biomimetic reactivity.
Authors
- Santina Hoof (ORCID: https://orcid.org/0000-0001-5512-3671)
- Ariane Jalila Simaan (ORCID: https://orcid.org/0000-0003-2537-0422)
- Christian Limberg (ORCID: https://orcid.org/0000-0002-0751-1386)
- Lars Müller (ORCID: https://orcid.org/0000-0002-2613-4221)
- Charikleia Tzatza
Institutions
- Centre National de la Recherche Scientifique (FR)
- Humboldt-Universität zu Berlin (DE)
- Centrale Méditerranée (FR)
Publication Details
- Journal
- JBIC Journal of Biological Inorganic Chemistry
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1007/s00775-025-02125-w
- Primary Topic
- Metal-Catalyzed Oxygenation Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00