SPP1+ Neutrophils Mediate Resistance to Immune Checkpoint Blockade in BAP1-Inactivated Tumors
BAP1 inactivation induces immunotherapy resistance and engenders an immunosuppressive microenvironment by enhancing CCL2 secretion and SPP1+ neutrophil polarization, which can be circumvented with CCL2-CCR2 inhibition to restore immune checkpoint blockade sensitivity.
Authors
- Yixiong Zhou (ORCID: https://orcid.org/0000-0001-9976-610X)
- Zhe Zhang (ORCID: https://orcid.org/0000-0003-0746-7589)
- Jianfeng Shen (ORCID: https://orcid.org/0000-0001-9779-6225)
- Xianqun Fan (ORCID: https://orcid.org/0000-0002-9394-3969)
- Guopei Zheng (ORCID: https://orcid.org/0000-0001-5896-5743)
- Jiahao Shi (ORCID: https://orcid.org/0009-0006-7548-6959)
- Shiyun Huang (ORCID: https://orcid.org/0009-0000-5561-9677)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4962
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05