Prospective evaluation of clinical characteristics, treatment efficacy, and seizure remission in adult‐onset genetic generalized epilepsy

This study evaluated adults experiencing their first seizures who were diagnosed with a type of epilepsy called genetic generalized epilepsy (GGE). We found that this condition can begin in adulthood, and many patients have a family history of seizures. Most responded well to treatment, frequently with just one medication, and only a few continued to have seizures. In some, particularly those with generalized tonic-clonic seizures (whole-body convulsions), treatment could be safely stopped after several seizure-free years. These findings highlight the importance of accurate diagnosis and provide reassurance that good seizure control is achievable for most adults with GGE.

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Publication Details

Journal
Epilepsia Open
Published
2025-09-13
DOI
https://doi.org/10.1002/epi4.70141
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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Prospective evaluation of clinical characteristics, treatment efficacy, and seizure remission in adult‐onset genetic generalized epilepsy

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Prospective evaluation of clinical characteristics, treatment efficacy, and seizure remission in adult‐onset genetic generalized epilepsy

Hassan Toufaili, Fatima Jaafar, Ayman Beydoun, Jaafar Wazne, Ahmad Beydoun, Ali Harb, Badiee Moussa, Lourdes Khalife
article en

Abstract

This study evaluated adults experiencing their first seizures who were diagnosed with a type of epilepsy called genetic generalized epilepsy (GGE). We found that this condition can begin in adulthood, and many patients have a family history of seizures. Most responded well to treatment, frequently with just one medication, and only a few continued to have seizures. In some, particularly those with generalized tonic-clonic seizures (whole-body convulsions), treatment could be safely stopped after several seizure-free years. These findings highlight the importance of accurate diagnosis and provide reassurance that good seizure control is achievable for most adults with GGE.

Epilepsia OpenVol. 10(5)
Rafik Hariri University Hospital (LB), American University of Beirut Medical Center (LB), Hammoud Hospital University Medical Center (LB)
Openalex Percentile: Top 71%
Epilepsy research and treatment
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