FBXW11 inhibits tumorigenesis by ubiquitinating YB1 in hepatocarcinoma
FBXW11 acts as a tumor suppressor in HCC by mediating YB1 ubiquitination and degradation, thereby inhibiting the Akt/mTOR pathway. The FBXW11-YB1 axis represents a novel regulatory mechanism in hepatocarcinogenesis, highlighting FBXW11 as a potential prognostic biomarker and therapeutic target for HCC.
Authors
- Bing Xu (ORCID: https://orcid.org/0000-0002-7271-4438)
- Wuguang Liu (ORCID: https://orcid.org/0000-0003-1180-9529)
- Chengyong Dong (ORCID: https://orcid.org/0000-0002-6461-8833)
- Xiaolong Liu (ORCID: https://orcid.org/0000-0003-1236-1332)
- Tong Wang (ORCID: https://orcid.org/0000-0002-0730-7481)
- Liming Wang (ORCID: https://orcid.org/0000-0003-0914-6113)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1007/s00432-025-06307-6
- Citations
- 1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.81