Interaction and Reciprocal Stabilization of H3.3 and PARP1 Promote DNA Damage Repair and Tumor Progression in Small Cell Lung Cancer
H3.3 binds and stabilizes PARP1 to support genomic stability and progression in small cell lung cancer, identifying a nontranscriptional tumor-promoting function of H3.3 and suggesting the potential for targeting the H3.3-PARP1 axis.
Authors
- Xinhuang Yao (ORCID: https://orcid.org/0000-0002-2295-939X)
- Wenchu Lin (ORCID: https://orcid.org/0000-0001-6141-1725)
- Li Xiang (ORCID: https://orcid.org/0000-0002-7164-0588)
- Dongdong Luo (ORCID: https://orcid.org/0000-0001-6428-9729)
- Yong Peng (ORCID: https://orcid.org/0000-0002-1181-3467)
- Gongfeng Li (ORCID: https://orcid.org/0009-0006-8488-1053)
- Jiahui Zhang (ORCID: https://orcid.org/0000-0002-2013-0289)
- Xiaolin Wang (ORCID: https://orcid.org/0000-0001-9171-4073)
- Peng Hou (ORCID: https://orcid.org/0009-0004-7110-0196)
- Liying Ma (ORCID: https://orcid.org/0009-0002-8046-8721)
- Guozhen Cao (ORCID: https://orcid.org/0000-0002-0213-7153)
- Jiarong Wang (ORCID: https://orcid.org/0000-0001-9152-5408)
- Jinghan Hua (ORCID: https://orcid.org/0009-0003-5618-1234)
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Chinese Academy of Sciences (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Longgang Central Hospital (CN)
- High Magnetic Field Laboratory (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4245
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00