Effects of neonatal hypothyroidism on testicular development and undifferentiated spermatogonia in prepubertal rats
This study demonstrated that even low-dose transient hypothyroidism during the neonatal period enhances the population of undifferentiated germ cells, potentially including spermatogonial stem cells. The transient hypothyroidism model offers a physiologically relevant and minimally invasive platform to explore how early thyroid hormone imbalances influence germ cell population establishment during a critical window of testicular development, potentially reflecting the clinical scenarios of treated congenital hypothyroidism.
Authors
- Akihiro Nakane (ORCID: https://orcid.org/0000-0003-4922-6978)
- Tetsuji Maruyama (ORCID: https://orcid.org/0000-0001-7270-1170)
- Hidenori Nishio (ORCID: https://orcid.org/0000-0003-1327-6631)
- Satoshi Kurokawa
- Kentaro Mizuno (ORCID: https://orcid.org/0000-0002-9624-2009)
- Takahiro Yasui
- Takuya Sakata
- Hideyuki Kamisawa
- Taiki Kato (ORCID: https://orcid.org/0000-0001-8788-9284)
- Daisuke Matsumoto (ORCID: https://orcid.org/0000-0002-3429-6554)
- Yutaro Hayashi
Institutions
- Nagoya City University (JP)
- Washington Adventist Hospital (US)
- Anjo Kosei Hospital (JP)
- Aichi University of Technology (JP)
Publication Details
- Journal
- Andrology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1111/andr.70116
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00