Inter‐Hospital Spread of Fluconazole‐Resistant <scp><i>C. parapsilosis</i></scp> in Northern Italy: Insights Into Clonal Distribution, Resistance Mechanisms and Biofilm Production
Our results confirmed that Y132F may be mainly responsible for azole resistance in C. parapsilosis and inter-hospital spread. As we found, recent clinical studies indicate that FRCP isolates responsible for severe outbreaks produce thin biofilms. Mutated and therefore resistant strains may exhibit reduced biofilm production as a protective mechanism.
Authors
- Roberta Schiavo (ORCID: https://orcid.org/0000-0003-0286-039X)
- Giorgia Palladini (ORCID: https://orcid.org/0009-0003-6954-8779)
- C. Cavanna (ORCID: https://orcid.org/0000-0003-2381-5213)
- A. Zappavigna
- Valentina Lepera (ORCID: https://orcid.org/0000-0001-6269-3330)
- Noel J. Ferraro
- Fausto Baldanti (ORCID: https://orcid.org/0000-0002-3358-8969)
- Guglielmo Ferrari (ORCID: https://orcid.org/0000-0003-1478-6094)
- Anna Prigitano (ORCID: https://orcid.org/0000-0001-8221-7542)
- Gabriella Tocci
- Elizabeth Iskandar
- Serena Trubini
- Giuliana Lo Cascio (ORCID: https://orcid.org/0000-0003-3971-2008)
Institutions
- University of Parma (IT)
- University of Milan (IT)
- University of Pavia (IT)
- Azienda Unità Sanitaria Locale Piacenza (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Mycoses
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/myc.70111
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Ministero della Salute