Safety of Baclofen and Tizanidine in Older Adults: A Retrospective Cohort Study in a Large Integrated Health Care System
Older adult patients dispensed baclofen or tizanidine were found to have an increased risk of injury when compared with cyclobenzaprine, currently included on the Beers Criteria. These findings support the inclusion of baclofen and tizanidine on the Beers Criteria along with other SMRs as potentially inappropriate medications in use in older adults with musculoskeletal complaints. Due to a retrospective design, the risk for residual confounding may remain.
Authors
- Joanie Chung (ORCID: https://orcid.org/0000-0002-7344-7861)
- Robert L. Deamer (ORCID: https://orcid.org/0009-0009-6895-1586)
- Jasmine Jafari
- Jing Zhang (ORCID: https://orcid.org/0000-0002-6566-6693)
- Monique Margaret George (ORCID: https://orcid.org/0009-0003-7346-2230)
- Dounia Bitar
- Erin L. Adams
- Sunha Lee-Rodriguez
Institutions
- Kaiser Permanente (US)
- Los Angeles Medical Center (US)
- Woodland Hills Medical Center (US)
- Virtual Reality Medical Center (US)
- Kaiser Permanente West Los Angeles Medical Center (US)
- Kaiser Permanente Capitol Hill Medical Center (US)
Publication Details
- Journal
- Journal of the American Geriatrics Society
- Published
- 2025-09-13
- DOI
- https://doi.org/10.1111/jgs.70097
- Citations
- 2
- Primary Topic
- Botulinum Toxin and Related Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Kaiser Permanente