Maternal-infant rotavirus-specific antibody kinetics to inform timing of vaccine boosting in Malawi: An observational study
These findings suggest that administering a booster dose between 6 and 8 months of age, when maternal antibody titer is low and severe rotavirus gastroenteritis risk is high, may enhance the immunogenicity and effectiveness of the rotavirus vaccine in LMICs.
Authors
- Martha Moyo
- Kayla G. Barnes (ORCID: https://orcid.org/0000-0002-8291-4388)
- Marc Henrion (ORCID: https://orcid.org/0000-0003-1242-839X)
- Khuzwayo C. Jere (ORCID: https://orcid.org/0000-0003-3376-8529)
- Kondwani Jambo (ORCID: https://orcid.org/0000-0002-3195-2210)
- Memory Mvula
- Jonathan Mandolo (ORCID: https://orcid.org/0000-0003-0143-7469)
- Nigel A. Cunliffe (ORCID: https://orcid.org/0000-0002-5449-4988)
- Fatima Mtonga
- Leah Mulira
- Willy Wotcheni
Institutions
- Broad Institute (US)
- University of Liverpool (GB)
- Liverpool School of Tropical Medicine (GB)
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme (MW)
- Kamuzu Central Hospital (MW)
- Kamuzu University of Health Sciences (MW)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1371/journal.pmed.1004734
- Citations
- 4
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.58