Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma

GSK3α/β and TSC2/mTORC1 are key downstream effectors of AKT in liver tumorigenesis that can potentially be targeted to benefit patients with hepatocellular carcinoma harboring aberrantly activated AKT.

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Publication Details

Journal
Cancer Research
Published
2025-09-12
DOI
https://doi.org/10.1158/0008-5472.can-25-1615
Primary Topic
FOXO transcription factor regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma

Shanshan Deng, Binyong Liang, Haichuan Wang, Lihui Yang et al.
Cancer Research
FOXO transcription factor regulation
article

Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma

Shanshan Deng, Binyong Liang, Haichuan Wang, Lihui Yang, Jingxiao Wang, Youping Deng, Xue Wang, Weiting Liao, Guofei Cui, Yi Zhou, Lucie David, Diego F. Calvisi, Jinghua Li, Andrew Yonemura, Xin Chen, Shu Zhang, Jinqiu Zhao, Eleonora Cossu, Xinjun Lu, Sheng Zhong, Meng Xu, Matthias Evert, Juliette M. Doumergue
article en

Abstract

GSK3α/β and TSC2/mTORC1 are key downstream effectors of AKT in liver tumorigenesis that can potentially be targeted to benefit patients with hepatocellular carcinoma harboring aberrantly activated AKT.

Cancer ResearchVol. 85(24)
University of Hawaiʻi at Mānoa (US), University of Hawaii System (US), Sun Yat-sen University (CN), Beijing University of Chinese Medicine (CN), University of California, San Francisco (US), Sichuan University (CN), West China Hospital of Sichuan University (CN), Cancer Center of Hawaii (US), Sun Yat-sen Memorial Hospital (CN), Sichuan Cancer Hospital (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Chongqing Institute of Green and Intelligent Technology (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), Tongji Hospital (CN), UCSF Helen Diller Family Comprehensive Cancer Center (US), University of Hawaii Cancer Center, Huazhong University of Science and Technology (CN), University of Regensburg (DE), Chongqing Medical University (CN)
Openalex Percentile: Top 78%
FOXO transcription factor regulation
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