Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma
GSK3α/β and TSC2/mTORC1 are key downstream effectors of AKT in liver tumorigenesis that can potentially be targeted to benefit patients with hepatocellular carcinoma harboring aberrantly activated AKT.
Authors
- Shanshan Deng (ORCID: https://orcid.org/0000-0003-4646-5885)
- Binyong Liang (ORCID: https://orcid.org/0009-0006-2749-7434)
- Haichuan Wang (ORCID: https://orcid.org/0000-0002-6886-5698)
- Lihui Yang (ORCID: https://orcid.org/0009-0005-1261-1444)
- Jingxiao Wang (ORCID: https://orcid.org/0000-0002-7799-781X)
- Youping Deng (ORCID: https://orcid.org/0000-0002-5951-8213)
- Xue Wang (ORCID: https://orcid.org/0009-0009-4148-0788)
- Weiting Liao (ORCID: https://orcid.org/0000-0003-0667-2046)
- Guofei Cui (ORCID: https://orcid.org/0009-0005-5624-0403)
- Yi Zhou (ORCID: https://orcid.org/0009-0009-5559-3417)
- Lucie David (ORCID: https://orcid.org/0009-0008-0819-7107)
- Diego F. Calvisi (ORCID: https://orcid.org/0000-0002-6038-8567)
- Jinghua Li (ORCID: https://orcid.org/0000-0002-6755-955X)
- Andrew Yonemura (ORCID: https://orcid.org/0009-0009-5701-8678)
- Xin Chen (ORCID: https://orcid.org/0000-0002-9588-0164)
- Shu Zhang (ORCID: https://orcid.org/0009-0005-0368-9397)
- Jinqiu Zhao (ORCID: https://orcid.org/0000-0001-9745-3230)
- Eleonora Cossu (ORCID: https://orcid.org/0009-0004-3437-0066)
- Xinjun Lu (ORCID: https://orcid.org/0000-0002-7643-0854)
- Sheng Zhong (ORCID: https://orcid.org/0009-0000-6178-4505)
- Meng Xu (ORCID: https://orcid.org/0000-0003-3282-9318)
- Matthias Evert (ORCID: https://orcid.org/0009-0004-3978-8058)
- Juliette M. Doumergue (ORCID: https://orcid.org/0009-0003-6827-4761)
Institutions
- University of Hawaiʻi at Mānoa (US)
- University of Hawaii System (US)
- Sun Yat-sen University (CN)
- Beijing University of Chinese Medicine (CN)
- University of California, San Francisco (US)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Cancer Center of Hawaii (US)
- Sun Yat-sen Memorial Hospital (CN)
- Sichuan Cancer Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Chongqing Institute of Green and Intelligent Technology (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Tongji Hospital (CN)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- University of Hawaii Cancer Center
- Huazhong University of Science and Technology (CN)
- University of Regensburg (DE)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1615
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00