Sotagliflozin Reduces Glucose Absorption and Improves Ultrafiltration in a Rat Model of Chronic Peritoneal Exposure to High-Glucose Dialysate

High-glucose PDF significantly increased the peritoneal expressions of both SGLT1 and SGLT2, which in turn facilitated more glucose absorption, eventually leading to a vicious cycle. Sotagliflozin may emerge as a novel strategy in PD to reduce glucose diffusion and enhance ultrafiltration.

Authors

Yuanyuan Shi (ORCID: https://orcid.org/0000-0003-2997-4573)
Zhanzheng Zhao (ORCID: https://orcid.org/0000-0001-6079-1631)
Lijie Zhang (ORCID: https://orcid.org/0000-0002-9435-9799)
Zi Yang Jiang (ORCID: https://orcid.org/0000-0001-8800-0678)
Jing Xiao (ORCID: https://orcid.org/0000-0002-6525-252X)

Institutions

First Affiliated Hospital of Zhengzhou University (CN)

Publication Details

Journal: Blood Purification
Published: 2025-09-12
DOI: https://doi.org/10.1159/000547528
Primary Topic: Diabetes Treatment and Management
Type: article
Field-Weighted Citation Impact: 0.00

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article

Sotagliflozin Reduces Glucose Absorption and Improves Ultrafiltration in a Rat Model of Chronic Peritoneal Exposure to High-Glucose Dialysate

Yuanyuan Shi, Zhanzheng Zhao, Lijie Zhang, Zi Yang Jiang et al.

Sep 12, 2025

Blood Purification

Diabetes Treatment and Management

article

Sotagliflozin Reduces Glucose Absorption and Improves Ultrafiltration in a Rat Model of Chronic Peritoneal Exposure to High-Glucose Dialysate

Yuanyuan Shi, Zhanzheng Zhao, Lijie Zhang, Zi Yang Jiang, Jing Xiao

September 12, 2025article en

Abstract

High-glucose PDF significantly increased the peritoneal expressions of both SGLT1 and SGLT2, which in turn facilitated more glucose absorption, eventually leading to a vicious cycle. Sotagliflozin may emerge as a novel strategy in PD to reduce glucose diffusion and enhance ultrafiltration.

Blood PurificationVol. 54(12)

First Affiliated Hospital of Zhengzhou University (CN)

Openalex Percentile: Top 67%

Diabetes Treatment and Management

DOI Source OpenAlex

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