Experimental assessment of novel PET detector components for online imaging of radioactive ion beams
<i>Objective.</i>This work aims to evaluate the ability of novel detector components to measure with submillimeter resolution in beam positron emission tomography (PET) signals produced by<sup>10</sup>C and<sup>11</sup>C radioactive ion beams stopped in PMMA targets and to validate a simulation toolkit for reproducing beam physics and PET detector responses within the framework of the biomedical applications of radioactive ion beam (BARB) project.<i>Approach.</i>The PET system response was assessed by visualizing the radioactive distributions of the beams stopped in tissue surrogate phantoms, and the capacity of the simulation toolkit was evaluated by comparing the experimental results with simulations, both for the depth-dose distribution and PET imaging.<i>Main results.</i>The detector assembly accurately visualized the PET signal with submillimeter resolution, achieving the objective of measuring the difference in the positron range between<sup>10</sup>C and<sup>11</sup>C. The simulation toolkit effectively reproduced the beam characteristics and detector responses, showing a high degree of agreement between the simulated and experimental PET profiles under different beam delivery conditions.<i>Significance.</i>These findings demonstrate the precision and reliability of the novel in-beam PET detector technology and simulation toolkit for small animals, establishing a solid foundation for the second phase of the BARB project, which involves preclinical irradiation of living mice.
Authors
- Katia Parodi (ORCID: https://orcid.org/0000-0001-7779-6690)
- Christian Graeff (ORCID: https://orcid.org/0000-0002-5296-7649)
- G. Dedes
- E. Haettner (ORCID: https://orcid.org/0000-0002-5057-9853)
- C. Scheidenberger (ORCID: https://orcid.org/0000-0003-3409-0350)
- Munetaka Nitta (ORCID: https://orcid.org/0000-0002-1335-9536)
- P. G. Thirolf (ORCID: https://orcid.org/0000-0002-6191-3319)
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- Daria Boscolo (ORCID: https://orcid.org/0000-0001-5709-4472)
- Christoph Schuy (ORCID: https://orcid.org/0000-0001-8407-9358)
- Chiara Gianoli (ORCID: https://orcid.org/0000-0002-0106-7448)
- Han Gyu Kang (ORCID: https://orcid.org/0000-0001-5338-4819)
- Taiga Yamaya (ORCID: https://orcid.org/0000-0002-7825-1729)
- D. Kostyleva (ORCID: https://orcid.org/0000-0002-3809-3092)
- Uli Weber (ORCID: https://orcid.org/0000-0002-8147-0084)
- Giulio Lovatti (ORCID: https://orcid.org/0000-0002-9819-1452)
- Francesco A. Evangelista (ORCID: https://orcid.org/0000-0002-7917-6652)
- Beatrice Foglia (ORCID: https://orcid.org/0009-0003-7619-0955)
- Marco Pinto (ORCID: https://orcid.org/0000-0001-6835-2561)
- Mohammad Javad Safari (ORCID: https://orcid.org/0000-0003-3868-5212)
- Sivaji Purushotaman
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- Justus-Liebig-Universität Gießen (DE)
- Technische Universität Darmstadt (DE)
- National Institutes for Quantum Science and Technology (JP)
- Federico II University Hospital (IT)
- Technische Hochschule Mittelhessen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Physics in Medicine and Biology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1088/1361-6560/ae0674
- Citations
- 1
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 1.52