Association of Preoperative Gut Microbiota Disturbances with Postoperative Infectious Complications in Major Gastrointestinal Cancer Surgery: A Large-Scale Exploratory Study
Fecal lactic acid concentrations, A. muciniphila, and L. lactis were identified as factors associated with the development or suppression of postoperative infectious complications. These findings suggest novel avenues for predicting and managing infection risks through preoperative assessments and microbiota modulation.
Authors
- Shuta Yamamoto
- Shunsuke Onoe (ORCID: https://orcid.org/0000-0002-0498-5586)
- Takuya Sugimoto (ORCID: https://orcid.org/0000-0002-2048-5450)
- Yukihiro Yokoyama (ORCID: https://orcid.org/0000-0003-2385-5610)
- Tomoki Ebata (ORCID: https://orcid.org/0000-0002-8247-7050)
- Junpei Yamaguchi (ORCID: https://orcid.org/0000-0002-5892-5271)
- Takashi Asahara (ORCID: https://orcid.org/0000-0001-5126-0636)
- Takashi Mizuno (ORCID: https://orcid.org/0000-0001-5023-0734)
- Yukiko Kado
Institutions
- Yakult Honsha (Japan) (JP)
- Yakult Central Institute (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1245/s10434-025-18298-2
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42