Heart Failure with Preserved Ejection Fraction in Cancer Patients and Survivors. A Scientific Statement of the Heart Failure Association of the ESC and the ESC Council of Cardio-Oncology
Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized in cancer patients and survivors, yet it remains underdiagnosed and its epidemiology largely unknown. This statement underscores the imperative need to include HFpEF in the cardiotoxicities identified during or after anticancer treatments. It also highlights the prognostic value of pre-existing HFpEF for periprocedural and cardiotoxicity risk and it discusses the challenges in the diagnosis and treatment of HFpEF in cancer patients. It also explores the aetiologic role of anticancer therapies (chemotherapy, targeted and hormonal therapies and radiotherapy) in the pathogenesis of HFpEF. Special emphasis is given on the importance of considering HFpEF from cancer diagnosis throughout treatment and survivorship and provides useful insights for cardiologists and oncologists in the monitoring and management of these patients. Finally, it highlights the key gaps in current knowledge that require further investigation through well-designed research trials to enhance our understanding and improve clinical outcomes.
Authors
- Markus S. Anker (ORCID: https://orcid.org/0000-0002-4406-8555)
- Teresa López‐Fernández (ORCID: https://orcid.org/0000-0002-3414-7022)
- Ninian N. Lang (ORCID: https://orcid.org/0000-0001-8441-6887)
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- Gianluigi Savarese (ORCID: https://orcid.org/0000-0001-7732-0887)
- Amina Rakisheva (ORCID: https://orcid.org/0000-0001-9842-962X)
- Gerasimos S Filippatos (ORCID: https://orcid.org/0000-0002-5640-0332)
- Pietro Ameri (ORCID: https://orcid.org/0000-0001-7167-7287)
- Borja Ibáñez (ORCID: https://orcid.org/0000-0002-5036-254X)
- Anita Deswal (ORCID: https://orcid.org/0000-0002-6147-9591)
- Mariana Mirabel (ORCID: https://orcid.org/0000-0002-9969-8896)
- Carlo G. Tocchetti (ORCID: https://orcid.org/0000-0001-5983-688X)
- Dimitrios T. Farmakis (ORCID: https://orcid.org/0000-0001-8364-3447)
- Alexander Richard Lyon (ORCID: https://orcid.org/0000-0001-8026-840X)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Lisa Anderson (ORCID: https://orcid.org/0000-0001-5059-3551)
- Brenda Moura (ORCID: https://orcid.org/0000-0001-6158-7368)
- Jutta K Bergler-Klein (ORCID: https://orcid.org/0000-0003-2591-1380)
- Kalliopi Keramida (ORCID: https://orcid.org/0000-0002-9533-6951)
- Walter J. Paulus
- Marco Metra
- Michele Senni
Institutions
- Almaty Management University (KZ)
- The University of Texas MD Anderson Cancer Center (US)
- Inserm (FR)
- St George's, University of London (GB)
- National University of Singapore (SG)
- National and Kapodistrian University of Athens (GR)
- Spanish National Centre for Cardiovascular Research (ES)
- Karolinska Institutet (SE)
- British Heart Foundation (GB)
- Institute Mutualiste Montsouris (FR)
- Stockholm South General Hospital (SE)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Royal Brompton Hospital (GB)
- Surgical Specialties (Canada) (CA)
- Hospital La Paz Institute for Health Research (ES)
- Deutsches Herzzentrum der Charité (DE)
- Ospedale Papa Giovanni XXIII (IT)
- Amsterdam Neuroscience (NL)
- Hospital Universitario Quirónsalud Madrid (ES)
- CUF Porto Hospital (PT)
- Centro de Investigación Biomédica en Red (ES)
- Federico II University Hospital (IT)
- St Savas Hospital (GR)
- German Centre for Cardiovascular Research (DE)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Paris Cardiovascular Research Center (FR)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Ospedale Policlinico San Martino (IT)
- National Heart Centre Singapore (SG)
- Amsterdam University Medical Centers (NL)
- University of Milano-Bicocca (IT)
- Medical University of Vienna (AT)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- University of Brescia (IT)
- University of Genoa (IT)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1002/ejhf.70005
- Citations
- 3
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 4.16