CT-based radiomics models decode fibrosis content and molecular differences in pancreatic ductal adenocarcinoma: a multi-institutional study
Fibrosis grading is of prognostic significance in pancreatic ductal adenocarcinoma (PDAC), but lacks a reliable preoperative assessment. The CT-based combined phase (CP) radiomics model predicts fibrosis grading effectively in PDAC. The CP radiomics model demonstrated prognostic and neoadjuvant chemotherapy efficacy evaluation value and underlying biological processes, which related fibrotic production and remodeling processes.
Authors
- Jianwei Xu (ORCID: https://orcid.org/0000-0001-8487-6728)
- Dexin Yu (ORCID: https://orcid.org/0000-0002-3430-4817)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6028-2554)
- Yufan Chen (ORCID: https://orcid.org/0000-0001-7989-3283)
- Guotao Yin
- Fangqing Wang
- Yang Sun (ORCID: https://orcid.org/0000-0002-1326-2259)
Institutions
- Shandong Provincial Hospital (CN)
- Liaocheng People's Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Insights into Imaging
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1186/s13244-025-02036-z
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Natural Science Foundation of Shandong Province