Association of metformin use with primary open-angle glaucoma using data from the National Institutes of Health <i>All of Us</i> Program
This study provides additional large-scale observational health data supporting the protective role of metformin in the development of POAG. However, limitations include the study's observational design and lack of data on metformin dosage and duration, glaucoma severity and ocular exam findings. Despite these limitations, our findings contribute to the growing body of evidence suggesting a potential protective effect of metformin against POAG.
Authors
- Sophia Sidhu (ORCID: https://orcid.org/0000-0001-5371-3483)
- Sasan Moghimi (ORCID: https://orcid.org/0000-0002-9375-4711)
- Bharanidharan Radha Saseendrakumar (ORCID: https://orcid.org/0000-0003-1322-4727)
- Robert Neal Weinreb (ORCID: https://orcid.org/0000-0001-9553-3202)
- Jo‐Hsuan Wu (ORCID: https://orcid.org/0000-0002-9435-746X)
- L. Jiun (ORCID: https://orcid.org/0000-0003-4768-0624)
- Sally L. Baxter (ORCID: https://orcid.org/0000-0002-5271-7690)
- Eric Nudleman (ORCID: https://orcid.org/0000-0002-9467-1563)
- Varsha Varkhedi (ORCID: https://orcid.org/0009-0002-6675-8191)
- Aman Parikh
Institutions
- University of California San Diego (US)
Publication Details
- Journal
- BMJ Open Ophthalmology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/bmjophth-2024-002027
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Institutes of Health
- University of California, San Diego
- School of Medicine, University of California, San Diego