Artemisinin derivatives modulate KEAP1-NRF2-xCT pathway to alleviate Sjögren’s disease: insights from scRNA-seq and systems biology
ART ameliorates SJD in NOD/Ltj mice by suppressing SGEC ferroptosis through the KEAP1-NRF2 pathway, highlighting its potential as a therapeutic agent for SJD.
Authors
- Genhong Yao (ORCID: https://orcid.org/0000-0003-4630-976X)
- Yanan Wang (ORCID: https://orcid.org/0000-0001-7481-4531)
- Xiaojun Tang (ORCID: https://orcid.org/0000-0001-8757-0927)
- Chang Liu (ORCID: https://orcid.org/0000-0001-9251-708X)
- Yong Luo (ORCID: https://orcid.org/0000-0003-3614-4359)
- Qingqing Yang (ORCID: https://orcid.org/0009-0002-0698-5499)
- Liuting Zeng
- Lingyun Sun
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1626230
- Citations
- 3
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China
- Nanjing Drum Tower Hospital
- Nanjing Medical Science and Technique Development Foundation
- National Key Research and Development Program of China