Ethyl pyruvate shields the brain from oxidative damage: a Keap1-Nrf2-dependent mechanism in subarachnoid hemorrhage
EP alleviates oxidative stress and neuronal damage following SAH by regulating the Keap1-Nrf2 signaling pathway. These results demonstrate EP's potential as a treatment approach that shows promise for enhancing patient outcomes in SAH.
Authors
- Zhenfei Teng
- Zelin Hao
- Wusi Qiu
- Jianyue Wu
- Mei Zhang (ORCID: https://orcid.org/0000-0003-0976-3867)
- Xi Deng (ORCID: https://orcid.org/0000-0001-8694-9572)
- Haisong Xu
- Hai Yu (ORCID: https://orcid.org/0000-0002-8296-2996)
- Jun Cheng
Institutions
- Affiliated Hospital of Hangzhou Normal University (CN)
Publication Details
- Journal
- Brain Research
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1016/j.brainres.2025.149939
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00