Multiomics Integration of Epigenetics, Proteomics, and Metabolomics Identifies Putative Drug Targets and Improves Early Prediction for Diabetes
A total of 175 CpGs, 29 proteins, and 93 metabolites were identified as associated with diabetes, among which 43 CpGs and 25 metabolites were validated in an independent cohort. Causal and mediation analyses revealed 20 biomarkers and 190 signaling pathways involved in diabetes development. The integrative multiomics prioritization provides the community with an ordered list of diabetes biomarkers. We experimentally validated one of the prioritized proteins, COLEC11, and demonstrated its involvement in lipid metabolism. Our findings prioritize potential therapeutic targets and demonstrate that integrating multiomics biomarkers improves diabetes risk prediction beyond traditional clinical models.
Authors
- Yingyu Cheng
- Aoyuan Cui (ORCID: https://orcid.org/0000-0003-2037-9241)
- Huating Li (ORCID: https://orcid.org/0000-0003-0526-5545)
- Geng Zong (ORCID: https://orcid.org/0000-0002-0372-8262)
- Qi Wang (ORCID: https://orcid.org/0000-0001-6740-8447)
- Qianqian Peng (ORCID: https://orcid.org/0000-0002-2018-5706)
- Mingfeng Xia (ORCID: https://orcid.org/0000-0002-4987-5866)
- Jiucun Wang (ORCID: https://orcid.org/0000-0003-2765-0620)
- Bing‐Hua Jiang (ORCID: https://orcid.org/0000-0003-4526-2031)
- Wenran Li (ORCID: https://orcid.org/0000-0002-1712-6895)
- Huiru Tang (ORCID: https://orcid.org/0000-0002-7139-2756)
- Qingxia Huang (ORCID: https://orcid.org/0000-0001-6549-2737)
- Yu Li (ORCID: https://orcid.org/0000-0001-6910-5933)
- Jin Li (ORCID: https://orcid.org/0000-0001-9201-2321)
- Jiarui Li (ORCID: https://orcid.org/0000-0003-0581-5850)
- Xin D. Gao (ORCID: https://orcid.org/0000-0002-7108-3574)
- Yan Zheng (ORCID: https://orcid.org/0000-0002-9602-1644)
- Chen Ding (ORCID: https://orcid.org/0000-0001-8673-3464)
- Jian‐Ge Qiu (ORCID: https://orcid.org/0000-0002-2215-2449)
- Sijia Wang
- Mengyao Huang
- Yong Wang (ORCID: https://orcid.org/0000-0003-0695-5273)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
- Fudan University Shanghai Cancer Center (CN)
- National Center for Mathematics and Interdisciplinary Sciences (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Shanghai Sixth People's Hospital (CN)
- Medical Technologies (Czechia) (CZ)
Publication Details
- Journal
- Diabetes
- Published
- 2025-09-12
- DOI
- https://doi.org/10.2337/db25-0354
- Citations
- 6
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.84